Full name: N-myristoyltransferase 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: HsNMT1; NMT

Summary: Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

Expression: Ubiquitous expression in brain (RPKM 21.5), thyroid (RPKM 17.0) and 25 other tissues

Gene size: 47700bp

Exon count: 12