Full name: NADH:ubiquinone oxidoreductase subunit B3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: B12; CI-B12; MC1DN25

Summary: This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]

Expression: Ubiquitous expression in kidney (RPKM 29.7), colon (RPKM 28.4) and 24 other tissues

Gene size: 13750bp

Exon count: 4