Full name: MAGUK p55 scaffold protein 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AAG12; DXS552E; EMP55; MRG1; PEMP

Summary: This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Expression: Broad expression in placenta (RPKM 52.9), bone marrow (RPKM 48.1) and 25 other tissues

Gene size: 26802bp

Exon count: 14