Full name: arylsulfatase B

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ASB; G4S; MPS6

Summary: Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]

Expression: Ubiquitous expression in kidney (RPKM 2.5), placenta (RPKM 1.5) and 25 other tissues

Gene size: 208750bp

Exon count: 17