PAIP2B poly(A) binding protein interacting protein 2B [ Homo sapiens (human) ] - Gene - Data resources

400961

PAIP2B poly(A) binding protein interacting protein 2B [ Homo sapiens (human) ]
Source: NCBI Gene (ID 400961)

Symbol: PAIP2B

Full name: poly(A) binding protein interacting protein 2B

Gene type: protein coding

RefSeq status: VALIDATED

Summary: Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]

Expression: Broad expression in brain (RPKM 9.7), thyroid (RPKM 9.0) and 23 other tissues

Orthologs: mouse

Gene size: 44366bp

Exon count: 6