Full name: LCK proto-oncogene, Src family tyrosine kinase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: IMD22; LSK; YT16; p56lck; pp58lck

Summary: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

Expression: Biased expression in lymph node (RPKM 46.5), appendix (RPKM 22.7) and 9 other tissues

Gene size: 34901bp

Exon count: 13