Parl presenilin associated, rhomboid-like [ Mus musculus (house mouse) ] - Gene - Data resources

381038

Parl presenilin associated, rhomboid-like [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 381038)

Symbol: Parl

Full name: presenilin associated, rhomboid-like

Gene type: protein coding

RefSeq status: PROVISIONAL

Also known as: D16Ertd607e; PRO2207; PSARL1; PSENIP2; Psarl

Summary: Enables endopeptidase activity. Involved in several processes, including mitochondrial fusion; negative regulation of apoptotic signaling pathway; and regulation of autophagy of mitochondrion. Located in mitochondrial inner membrane. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in bladder adult (RPKM 19.4), testis adult (RPKM 16.4) and 28 other tissues

Orthologs: human

Gene size: 22592bp

Exon count: 10