Full name: potassium inwardly rectifying channel subfamily J member 6

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BIR1; GIRK-2; GIRK2; KATP-2; KATP2; KCNJ7; KIR3.2; KPLBS; hiGIRK2

Summary: This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]

Expression: Biased expression in brain (RPKM 1.1), stomach (RPKM 0.3) and 7 other tissues

Gene size: 309085bp

Exon count: 4