Full name: CD82 molecule

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6; TSPAN27

Summary: This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in esophagus (RPKM 44.7), bone marrow (RPKM 32.0) and 25 other tissues

Gene size: 55950bp

Exon count: 12