Full name: integrin subunit alpha V

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CD51; MSK8; VNRA; VTNR

Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Expression: Ubiquitous expression in thyroid (RPKM 45.9), ovary (RPKM 36.3) and 24 other tissues

Gene size: 90846bp

Exon count: 32