Full name: integrin subunit alpha 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2

Summary: This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Expression: Broad expression in skin (RPKM 8.4), adrenal (RPKM 7.9) and 21 other tissues

Gene size: 105428bp

Exon count: 30