Full name: X-linked inhibitor of apoptosis

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP-3; hIAP3

Summary: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

Expression: Ubiquitous expression in thyroid (RPKM 10.5), colon (RPKM 8.6) and 25 other tissues

Gene size: 54265bp

Exon count: 10