Full name: homeobox D3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: HOX1D; HOX4; HOX4A; Hox-4.1

Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]

Expression: Biased expression in kidney (RPKM 1.9), endometrium (RPKM 1.4) and 11 other tissues

Gene size: 20570bp

Exon count: 10