Full name: DEAD/H box helicase 11

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 4732462I11Rik; CHL1; CHLR1; KRG2; essa15a

Summary: Predicted to enable several functions, including 5'-3' DNA helicase activity; ATP-dependent activity, acting on RNA; and nucleic acid binding activity. Predicted to be involved in DNA duplex unwinding and establishment of sister chromatid cohesion. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Is expressed in allantois; embryo; placenta; and yolk sac endoderm. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 5.7) and 27 other tissues

Gene size: 28662bp

Exon count: 26