Full name: amyloid beta precursor protein binding family A member 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA

Summary: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

Expression: Broad expression in brain (RPKM 13.2), spleen (RPKM 2.4) and 17 other tissues

Gene size: 245482bp

Exon count: 15