Full name: HLF transcription factor, PAR bZIP family member

Gene type: protein coding

RefSeq status: REVIEWED

Summary: This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Expression: Broad expression in liver (RPKM 22.6), brain (RPKM 22.4) and 18 other tissues

Gene size: 60228bp

Exon count: 9