Full name: annexin A5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3; VAC-alph

Summary: The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019]

Expression: Ubiquitous expression in fat (RPKM 198.4), placenta (RPKM 170.8) and 25 other tissues

Gene size: 29035bp

Exon count: 13