Full name: histone deacetylase 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HD2; KDAC2; RPD3; YAF1

Summary: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Expression: Ubiquitous expression in testis (RPKM 14.8), endometrium (RPKM 10.6) and 25 other tissues

Gene size: 38121bp

Exon count: 17