Full name: caspase recruitment domain family member 10

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BIMP1; CARMA3; IMD89

Summary: The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

Expression: Broad expression in small intestine (RPKM 15.9), duodenum (RPKM 15.0) and 22 other tissues

Gene size: 29054bp

Exon count: 20