Full name: PYD and CARD domain containing

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ASC; CARD5; TMS; TMS-1; TMS1

Summary: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Broad expression in spleen (RPKM 25.5), colon (RPKM 25.4) and 22 other tissues

Gene size: 1275bp

Exon count: 3