Full name: mitochondrial ribosomal protein L15

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HSPC145; L15mt; MRP-L15; MRP-L7; RPML7

Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in heart (RPKM 21.7), kidney (RPKM 16.2) and 25 other tissues

Gene size: 13274bp

Exon count: 5