Full name: glutamate ionotropic receptor kainate type subunit 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: EAA5; GLR7; GLUR7; GluK3; GluR7a

Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

Expression: Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues

Gene size: 238989bp

Exon count: 16