Full name: angiopoietin 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AGPT2; ANG2; LMPHM10

Summary: This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]

Expression: Broad expression in placenta (RPKM 6.2), urinary bladder (RPKM 5.1) and 19 other tissues

Gene size: 63614bp

Exon count: 9