Full name: angiopoietin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AGP1; AGPT; AGPT-1; ANG1; HAE5

Summary: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema. [provided by RefSeq, Aug 2020]

Expression: Broad expression in fat (RPKM 19.0), lung (RPKM 14.2) and 20 other tissues

Gene size: 248437bp

Exon count: 10