Full name: ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 2900011L11Rik; Abcc5a; Abcc5b; Mrp5

Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in CNS E18 (RPKM 26.0), CNS E14 (RPKM 23.9) and 26 other tissues

Gene size: 95126bp

Exon count: 34