GLI1 GLI family zinc finger 1 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 2735)
Source: NCBI Gene (ID 2735)
Symbol: GLI1
Full name: GLI family zinc finger 1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: GLI; PAPA8; PPD1
Summary: This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Expression: Broad expression in endometrium (RPKM 5.6), testis (RPKM 2.9) and 15 other tissues
Orthologs: mouse
Gene size: 12484bp
Exon count: 13