Full name: LSM1 homolog, mRNA degradation associated

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CASM; YJL124C

Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

Expression: Ubiquitous expression in heart (RPKM 16.1), placenta (RPKM 14.6) and 25 other tissues

Gene size: 13410bp

Exon count: 5