Full name: TNF receptor superfamily member 21

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BM-018; CD358; DR6

Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

Expression: Broad expression in urinary bladder (RPKM 50.6), fat (RPKM 36.4) and 23 other tissues

Gene size: 78374bp

Exon count: 6