AFF4 ALF transcription elongation factor 4 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 27125)
Source: NCBI Gene (ID 27125)
Symbol: AFF4
Full name: ALF transcription elongation factor 4
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: AF5Q31; CHOPS; MCEF
Summary: The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
Expression: Ubiquitous expression in thyroid (RPKM 21.2), adrenal (RPKM 17.6) and 25 other tissues
Orthologs: mouse
Gene size: 88240bp
Exon count: 23