Full name: AP2 associated kinase 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 5530400K14Rik; 9630042K20; D6Ertd245e; Gm38495; mKIAA1048

Summary: Predicted to enable AP-2 adaptor complex binding activity; Notch binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of Notch signaling pathway; protein stabilization; and regulation of clathrin-dependent endocytosis. Predicted to act upstream of or within endocytosis and phosphorylation. Predicted to be located in cell leading edge and terminal bouton. Predicted to be part of clathrin complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; dorsal root ganglion; retina nuclear layer; and telencephalon. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in cerebellum adult (RPKM 16.3), cortex adult (RPKM 15.4) and 24 other tissues

Gene size: 153958bp

Exon count: 23