Full name: estrogen related receptor, beta

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Err2; Errb; Estrrb; Nr3b2

Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of stem cell population maintenance; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within in utero embryonic development and positive regulation of transcription by RNA polymerase II. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in kidney adult (RPKM 6.2), heart adult (RPKM 4.9) and 12 other tissues

Gene size: 160512bp

Exon count: 11