Full name: UPF2 regulator of nonsense mediated mRNA decay

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HUPF2; RENT2; smg-3

Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in testis (RPKM 11.8), lymph node (RPKM 8.5) and 25 other tissues

Gene size: 123149bp

Exon count: 24