RCHY1 ring finger and CHY zinc finger domain containing 1 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 25898)
Source: NCBI Gene (ID 25898)
Symbol: RCHY1
Full name: ring finger and CHY zinc finger domain containing 1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363
Summary: The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in thyroid (RPKM 7.9), bone marrow (RPKM 6.3) and 25 other tissues
Orthologs: mouse
Gene size: 35683bp
Exon count: 10