Full name: SAM pointed domain containing ETS transcription factor

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PDEF; bA375E1.3

Summary: The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Expression: Biased expression in prostate (RPKM 50.1), salivary gland (RPKM 10.8) and 5 other tissues

Gene size: 18528bp

Exon count: 8