Full name: grainyhead like transcription factor 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 0610015A08Rik; BOM; Tcfcp2l3; clft3

Summary: Enables DNA-binding transcription factor activity; chromatin binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epithelial cell differentiation; neural tube closure; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and face development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in genital fat pad adult (RPKM 7.3), bladder adult (RPKM 5.9) and 14 other tissues

Gene size: 130749bp

Exon count: 18