Tox thymocyte selection-associated high mobility group box [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 252838)
Source: NCBI Gene (ID 252838)
Symbol: Tox
Full name: thymocyte selection-associated high mobility group box
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 1700007F02Rik
Summary: Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; positive regulation of DNA demethylation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 22.1), whole brain E14.5 (RPKM 7.5) and 16 other tissues
Orthologs: human
Gene size: 305205bp
Exon count: 12