Shank1 SH3 and multiple ankyrin repeat domains 1 [ Mus musculus (house mouse) ] - Gene - Data resources

243961

Shank1 SH3 and multiple ankyrin repeat domains 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 243961)

Symbol: Shank1

Full name: SH3 and multiple ankyrin repeat domains 1

Gene type: protein coding

RefSeq status: VALIDATED

Summary: Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and regulation of signal transduction. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in frontal lobe adult (RPKM 16.9), cortex adult (RPKM 13.3) and 9 other tissues

Orthologs: human

Gene size: 51176bp

Exon count: 32