Full name: tuftelin interacting protein 11

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: NTR1; STIP; STIP-1; Spp382; TIP39; bK445C9.6

Summary: This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Expression: Ubiquitous expression in testis (RPKM 20.2), bone marrow (RPKM 19.7) and 25 other tissues

Gene size: 21234bp

Exon count: 16