Full name: ring finger protein 13

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 2010001H16Rik; Rzf

Summary: This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]

Expression: Ubiquitous expression in cerebellum adult (RPKM 16.4), bladder adult (RPKM 14.8) and 28 other tissues

Gene size: 99379bp

Exon count: 12