Full name: ubiquitin specific peptidase 3

Gene type: protein coding

RefSeq status: REVIEWED

Summary: The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Expression: Ubiquitous expression in thymus adult (RPKM 7.4), cerebellum adult (RPKM 5.9) and 28 other tissues

Gene size: 80424bp

Exon count: 20