Full name: phosphoinositide-3-kinase regulatory subunit 5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: F730038I15Rik; FOAP-2; P101-PI3K; p101

Summary: Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

Expression: Biased expression in bone marrow (RPKM 25.8), spleen (RPKM 14.1) and 13 other tissues

Gene size: 86792bp

Exon count: 23