Scn3b sodium channel, voltage-gated, type III, beta [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 235281)
Source: NCBI Gene (ID 235281)
Symbol: Scn3b
Full name: sodium channel, voltage-gated, type III, beta
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 1110001K16Rik; 4833414B02Rik; Scnb3
Summary: Enables transmembrane transporter binding activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in SA node cell action potential; positive regulation of heart rate; and regulation of atrial cardiac muscle cell membrane depolarization. Acts upstream of or within cardiac conduction and ventricular cardiac muscle cell action potential. Located in Z disc. Is expressed in several structures, including gut; nervous system; sensory organ; skeletal musculature; and urinary system. Used to study Brugada syndrome 7. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 43.1), whole brain E14.5 (RPKM 26.9) and 7 other tissues
Orthologs: human
Gene size: 22403bp
Exon count: 6