Full name: solute carrier family 39 member 14

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HCIN; HMNDYT2; LZT-Hs4; NET34; ZIP14; cig19

Summary: This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]

Expression: Broad expression in liver (RPKM 83.2), duodenum (RPKM 51.4) and 20 other tissues

Gene size: 66852bp

Exon count: 16