Full name: SPG7, paraplegin matrix AAA peptidase subunit

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Cmar; PGN

Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and peptidase activity. Acts upstream of or within anterograde axonal transport and mitochondrion organization. Located in mitochondrial inner membrane. Part of m-AAA complex. Is expressed in central nervous system; olfactory epithelium; and retina nuclear layer. Used to study hereditary spastic paraplegia 7. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in adrenal adult (RPKM 106.3), duodenum adult (RPKM 72.3) and 28 other tissues

Gene size: 32253bp

Exon count: 17