Full name: chromobox 5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HEL25; HP1; HP1A

Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in brain (RPKM 15.3), thyroid (RPKM 14.2) and 25 other tissues

Gene size: 49181bp

Exon count: 6