COTL1 coactosin like F-actin binding protein 1 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 23406)
Symbol: COTL1
Full name: coactosin like F-actin binding protein 1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: CLP
Summary: This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lymph node (RPKM 178.3), appendix (RPKM 165.6) and 20 other tissues
Orthologs: mouse
Gene size: 52483bp
Exon count: 4