Full name: protein phosphatase 1 regulatory subunit 13B

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ASPP1; p53BP2-like; p85

Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

Expression: Broad expression in thyroid (RPKM 17.5), testis (RPKM 15.0) and 24 other tissues

Gene size: 115620bp

Exon count: 23