Full name: fibromodulin

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FM; SLRR2E

Summary: Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Expression: Broad expression in gall bladder (RPKM 78.8), fat (RPKM 77.4) and 22 other tissues

Gene size: 10495bp

Exon count: 4