Full name: sulfatase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: SULF-1

Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Expression: Broad expression in urinary bladder (RPKM 23.6), prostate (RPKM 21.2) and 19 other tissues

Gene size: 194132bp

Exon count: 26