Full name: F-box protein 21

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FBX21

Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in testis (RPKM 31.4), ovary (RPKM 26.9) and 25 other tissues

Gene size: 48480bp

Exon count: 12